when you ask someone a question and they just stare blankly at you like you didn't say anything

You ask your coworker if she wants coffee. She stares. You ask again, louder. Still staring. You assume she's having a stroke until she finally says, "Sorry, I was just thinking about whether penguins have knees." Apparently your question entered a waiting room behind her existential crisis and never made it to the front desk.
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when you're trying to ask someone something and they just answer a different question entirely

I asked my roommate if he'd seen my keys. He launched into a fifteen-minute explanation of why he switched to a subscription service for his socks. When he finally finished, I just held up the keys I'd found in the door. He nodded thoughtfully and said, "Yeah, the subscription really saves money in the long run."