when you're trying to explain something and people just don't get what you mean

You spend five minutes explaining why your ex was wrong for you, using hand gestures and everything. Your friend nods slowly and says, "So you're gonna give it another shot then?" You stare at her. She adds, helpfully, "Third time's the charm."
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when you're trying to explain something and someone just stares at you with a confused look like you're speaking a different language

You start explaining something perfectly simple—like how to reset your WiFi password—and their face goes completely blank, eyes locked on you like a cat watching a laser dot move across a wall. By the third sentence you're already simplifying: "It's on the back of the router." Blank stare. "The *router*. The box." Blanker. Eventually you're pointing at it in person while they nod and say "ohhh" in a way that suggests they still don't know what a router is, just that you seem very passionate about one particular corner of the room.